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Normally, however, these hypothalamic cells are only turned on sporadically, when a creature is faced with situations that demand arousal and cause acetylcholine to be secreted

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The moderating effect of OPRM1 is an exploratory aim given that: (i) there have been several investigations of the moderating role of this SNP on naltrexone in alcohol patients and (ii) the prevalence of Asp40 carriers is 1525% and potential under-sampling will, thus, reduce the power to test the effect